Bioactive Small Molecules
Cayman Chemical CurvularIa CurvulIn 5mg
A phytotoxin reported to inhibit microtubule assembly and iNOS expression
Cayman Chemical Curcuma zdoara Grmacron 5mg
A sesquiterpene with diverse biological activities; inhibits PRV replication in Vero cells from 10-150 µM; enhances doxorubicin-induced cytotoxicity and apoptosis in doxorubicin-resistant MCF-7/adr cells from 50-250 µM; reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity at 5, 10, and 20 mg/kg; decreases brain MDA levels and activity of SOD and GPX, as well as reduces infarct volume in a rat model of MCAO-induced ischemia-reperfusion injury
Cayman Chemical ANTIBODY IP7e 5mg
An activator of Nurr1 signaling (EC50 = 3.9 nM in a reporter assay); prevents spinal cord axonal loss and demyelination and decreases spinal cord macrophage and T cell infiltration in a mouse model of EAE at 10 mg/kg
Medchemexpress LLC Lyn-1604 dihydrochloride | 2310109-38-5 | 99.6% | 657.54 g/mol | C33H45Cl4N3O2 | 1 ML
LYN-1604 dihydrochloride is a research-grade small-molecule activator of UNC-51-like kinase 1 (ULK1) used to probe autophagy and cell death pathways in preclinical and in vitro studies, including triple-negative breast cancer models. The compound is supplied as a dihydrochloride salt in solution or solid forms for flexible experimental use.
- Potent ULK1 activation with EC50 18.94 nM.
- Available as 10 mM solution in DMSO and multiple solid sizes for convenient dosing.
- High purity material (99.6%).
- Accompanied by datasheet, certificate of analysis, and safety data sheet.
- Useful for studies of autophagy, apoptosis, and cancer biology.
Cayman Chemical PF-03550096 5mg
A synthetic CB that selectively targets the peripheral CB2 receptor over the central CB1 receptor (Kis = 7.9 and 1,500 nM for human isoforms, respectively); intended for forensic and research applications
Cayman Chemical ANTIBODY ETP-46321 25mg
A PI3K p110α and p110δ inhibitor (apparent Kis = 2.3 and 14.2 nM, respectively); selective for PI3K p110α and p110δ over p110β and p110γ (apparent Kis = 170 and 179 nM, respectively), as well as a panel of 288 kinases at 1 µM; inhibits Akt phosphorylation in U2OS cells (IC50 = 8.3 nM); reduces tumor volume in a K-RasG12V-driven murine lung tumor model at 50 mg/kg; reduces anti-collagen IgG1 and IgG2a production, swelling, and joint rigidity in a mouse model of collagen-induced arthritis
Cayman Chemical ANTIBODY TPX-0005 5mg
A multi-kinase inhibitor; inhibits TrkA, TrkB, and TrkC (IC50s = 0.83, 0.05, and 0.1 nM, respectively) as well as ROS1 (IC50 = 0.07 nM); inhibits a variety of other kinases, including ALK, JAK2, LYN, Src, and FAK (IC50s = 1.04, 1.04, 1.66, 5.3, and 6.96 nM, respectively); inhibits proliferation of PC-9, H1975, 11-18, HCC4006, and HCC827 cells (IC50s = 100, 100, 150, 148, and 430 nM, respectively) with additive or synergistic effects when used in combination with certain compounds, including osimertinib; reduces tumor growth in PC-9 and H1975 mouse xenograft models; potentiates the effect of osimertinib on tumor growth in vivo
Selleck Chemical LLC CCS-14775mg
CCS1477(CBP-IN-1, CBP/p300-IN-4)is a potent and selective inhibitor of p300/CBP bromodomain. CCS1477 works by inhibiting the expression and function of the androgen receptor (AR), as well as inhibiting c-Myc. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC 1,2-Dioleoyl-sn-glycero-3-phosphocholine | 4235-95-4 | 99.9% | 786.11 | 50 MG
1,2-Dioleoyl-sn-glycero-3-phosphocholine | 4235-95-4 | 99.9% | 786.11 | 50 MG
Cayman Chemical VardenafIl-d5 500ug
An internal standard for the quantification of vardenafil by GC- or LC-MS
Cayman Chemical SBI-0640756 10mg
An inhibitor of eIF4G1; inhibits the association of eIF4G1 with the eIF4F complex in UACC-903 cell lysates in an m7GTP-agarose pull-down assay at 0.75 µM; inhibits eIF4G1-dependent and -independent mRNA translation in reporter assays using rabbit reticulocyte lysates (IC50s = 3.83 and 4.59 µM, respectively); reduces the growth of 1205Lu, WM1346, A375, UACC-903, and WM3629 melanoma cells; decreases tumor incidence by 50% in an N-RasQ61K-expressing, Ink4a-/- murine melanoma model at 0.5 mg/kg; decreases tumor volume in an A375 mouse xenograft model when used in combination with PLX4720
Medchemexpress LLC 3-Amino-4-hydroxybenzoic acid | 1571-72-8 | MFCD00007697 | 99.86% | 153.14 | 100 G
3-Amino-4-hydroxybenzoic acid is an endogenous metabolite primarily intended for research use. It is recognized for its role as an important intermediate and a key component in pharmaceutical applications.
- Endogenous metabolite
- Primarily for research use
- Key intermediate in pharmaceutical synthesis
- Used in anti-tuberculosis drug development
- Identified in human serum
Medchemexpress LLC Ont-093 (oc 144-093) | 216227-54-2 | C32H38N4O | 1 MG
ONT-093 (OC 144-093) is a potent and orally active inhibitor of the P-glycoprotein pump, which mediates drug efflux and impacts bioavailability. It inhibits P-gp-mediated ATPase activity with an IC50 of 0.16 μM. This compound is capable of reversing multidrug resistance in cancer cells to chemotherapeutic drugs, making it suitable for research in cancer, such as colon cancer, and infections like malaria.
- Potent and orally active inhibitor of P-glycoprotein pump.
- Inhibits P-gp-mediated ATPase activity (IC50 of 0.16 μM).
- Reverses multidrug resistance in cancer cells to chemotherapeutic drugs.
- Useful for research in cancer and infections like malaria.
- Shows no significant cytotoxicity against normal and tumor cell lines.
Medchemexpress LLC 2,2'-Anhydrouridine | 3736-77-4 | MFCD00004945 | 99.5% | 226.19 | 50 G
2,2'-Anhydrouridine (2,2'-Cyclouridine) is a nucleoside analog and an important intermediate in the synthesis of other nucleoside-related compounds. The 5-substituted analogues of 2,2'-Anhydrouridine are competitive inhibitors of uridine phosphorylase.
- Nucleoside analog
- Important intermediate in the synthesis of other nucleoside-related compounds
- 5-substituted analogues are competitive inhibitors of uridine phosphorylase
Medchemexpress LLC NP3-562 | 2409825-32-5 | 98.2% | 437.94 | 50 MG
NP3-562 is an orally active NLRP3 Inhibitor that blocks IL-1β release in stimulated cells and in vivo models. It is suitable for acute peritonitis research.
- Orally active NLRP3 inhibitor
- Inhibits IL-1β release
- Used for acute peritonitis studies
- Demonstrates brain exposure